Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | CYP1A1 | P04798 | 5/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 5/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.41 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP4B1 | P13584 | 1/20 | 0.41 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.41 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.41 |
| ▸ | CYP2A7 | P20853 | 1/20 | 0.41 |
| ▸ | CYP3A7 | P24462 | 1/20 | 0.41 |
| ▸ | CYP2F1 | P24903 | 1/20 | 0.41 |
| ▸ | CYP2C18 | P33260 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7365190 | 0.86 | NPC1 (0.51) | NPC1RAB9ACYP1A1CYP1B1CYP1A2 | |
| SCHEMBL7366322 | 0.80 | ALDH1A1 (0.49) | NPC1RAB9AMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL4133106 | 0.72 | NPC1 (0.64) | NPC1RAB9ACYP1A1CYP1B1CYP1A2 | |
| SCHEMBL7365842 | 0.72 | TGFBR1 (0.70) | NPC1RAB9ATGFBR1TEKMAPK14 | |
| SCHEMBL7370785 | 0.72 | CYP3A4 (0.51) | NPC1RAB9ACYP1A1CYP1B1CYP1A2 | |
| SCHEMBL7372813 | 0.70 | TLR8 (0.35) | NPC1RAB9ATGFBR1TEKSMN1; SMN2 | |
| SCHEMBL7369909 | 0.70 | NPC1 (0.52) | NPC1RAB9ATGFBR1TEKMAPK14 | |
| SCHEMBL7373114 | 0.69 | TLR9 (0.43) | NPC1RAB9ACYP1A1CYP1B1MEN1 | |
| SCHEMBL7370568 | 0.68 | CYP3A4 (0.55) | NPC1RAB9ACYP1A1CYP1B1CYP1A2 | |
| SCHEMBL6283374 | 0.66 | CRHR1 (0.71) | CYP1A1CYP1B1CYP1A2CYP3A4CYP2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4822805-A | ANTIINFLAMMATORY AGENTS, CARDIOTONIC AGENTS, ANTIPLATELET AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-18 | — | — | US | disclosed |
| EP-0257897-A1 | Imidazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-02 | — | — | EP | disclosed |