Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 10/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 10/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | CTSA | P10619 | 3/20 | 0.43 |
| ▸ | SUCNR1 | Q9BXA5 | 2/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7368775 | 0.95 | ITGB3 (0.44) | ITGB3ITGA2BROCK2ROCK1CTSA | |
| SCHEMBL6433230 | 0.88 | ROCK2 (0.41) | ITGB3ITGA2BROCK2ROCK1 | |
| SCHEMBL7370207 | 0.86 | CASP3 (0.46) | ITGB3ITGA2B | |
| Trifluoroacetic Acid SCHEMBL7377943 | 0.81 | TMPRSS15 (0.44) | ITGB3ITGA2B | |
| Trifluoroacetic Acid SCHEMBL7450905 | 0.80 | CA2 (0.44) | ROCK2 | |
| Hydrochloric Acid SCHEMBL7447049 | 0.79 | CA1 (0.39) | ITGB3ITGA2B | |
| SCHEMBL7378240 | 0.79 | CA1 (0.42) | ITGB3ITGA2B | |
| SCHEMBL6437334 | 0.78 | ROCK2 (0.49) | ROCK2 | |
| Trifluoroacetic Acid SCHEMBL7368235 | 0.76 | CA2 (0.40) | ITGB3ITGA2B | |
| Trifluoroacetic Acid SCHEMBL7372144 | 0.76 | CA1 (0.36) | ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242120-A2 | COMBINATIONS OF GROWTH FACTORS AND I:UPA OR I:MMP FOR THE TREATMENT OF DAMAGED TISSUE | Pfizer Limited (GB) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001049309-A2 | COMBINATIONS OF GROWTH FACTORS AND I: UPA OR I: MMP FOR THE TREATMENT OF DAMAGED TISSUE | PFIZER LIMITED (GB) | 2001-07-12 | — | — | WO | disclosed |