Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 12/20 | 0.40 |
| ▸ | CA1 | P00915 | 11/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.38 |
| ▸ | TMPRSS15 | P98073 | 3/20 | 0.35 |
| ▸ | CA12 | O43570 | 3/20 | 0.35 |
| ▸ | CA9 | Q16790 | 3/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7377943 | 0.92 | TMPRSS15 (0.44) | CA2CA1ITGB3ITGA2BTMPRSS15 | |
| Trifluoroacetic Acid SCHEMBL7372438 | 0.91 | GRN (0.45) | CA2CA1ITGB3ITGA2BTMPRSS15 | |
| Trifluoroacetic Acid SCHEMBL7450905 | 0.91 | CA2 (0.44) | CA2CA1PTPN1 | |
| SCHEMBL7370207 | 0.86 | CASP3 (0.46) | CA2CA1ITGB3ITGA2BTMPRSS15 | |
| Trifluoroacetic Acid SCHEMBL7380314 | 0.86 | CA2 (0.40) | CA2CA1MRGPRX4 | |
| Trifluoroacetic Acid SCHEMBL7372144 | 0.83 | CA1 (0.36) | CA2CA1ITGB3ITGA2B | |
| Trifluoroacetic Acid SCHEMBL7368775 | 0.83 | ITGB3 (0.44) | ITGB3ITGA2B | |
| SCHEMBL6437334 | 0.78 | ROCK2 (0.49) | — | |
| Trifluoroacetic Acid SCHEMBL7368831 | 0.77 | F2 (0.46) | ITGB3ITGA2B | |
| Trifluoroacetic Acid SCHEMBL7372457 | 0.77 | MMP9 (0.45) | CA2CA1ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242120-A2 | COMBINATIONS OF GROWTH FACTORS AND I:UPA OR I:MMP FOR THE TREATMENT OF DAMAGED TISSUE | Pfizer Limited (GB) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001049309-A2 | COMBINATIONS OF GROWTH FACTORS AND I: UPA OR I: MMP FOR THE TREATMENT OF DAMAGED TISSUE | PFIZER LIMITED (GB) | 2001-07-12 | — | — | WO | disclosed |
| EP-1077945-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-2000005214-A2 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2000-02-03 | — | — | WO | disclosed |