Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7401060 | 0.81 | KDM4E (0.45) | KDM4EPKMGPR119FAAH | |
| SCHEMBL7399174 | 0.80 | ITGB3 (0.46) | KDM4EPKMGPR119FAAH | |
| SCHEMBL12736015 | 0.78 | KDM4E (0.56) | KDM4EPKMGPR119KMT2AFAAH | |
| SCHEMBL7440251 | 0.78 | KDM4E (0.53) | KDM4EPKMGPR119KMT2A | |
| SCHEMBL7399144 | 0.77 | GLS (0.45) | KDM4EPKMGPR119FAAH | |
| SCHEMBL1532734 | 0.77 | KDM4E (0.57) | KDM4EPKMGPR119KMT2A | |
| SCHEMBL7445509 | 0.76 | GLS (0.43) | KDM4EPKMGPR119FAAH | |
| SCHEMBL7403703 | 0.75 | FAAH (0.42) | KDM4EPKMGPR119FAAH | |
| SCHEMBL7402191 | 0.74 | GPR119 (0.55) | KDM4EPKMGPR119KMT2AFAAH | |
| SCHEMBL7397624 | 0.74 | KDM4E (0.44) | KDM4EPKMGPR119MMP13FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0664792-B1 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2000-01-05 | — | — | EP | disclosed |
| US-5721253-A | Fibrinogen receptor antagonists | MERCK & CO., INC. (US) | 1998-02-24 | — | — | US | disclosed |
| EP-0664792-A4 | FIBRINOGEN RECEPTOR ANTAGONISTS. | MERCK & CO INC (US) | 1996-09-25 | — | — | EP | disclosed |
| US-5559127-A | ANTICOAGULANTS | MERCK & CO., INC. (US) | 1996-09-24 | — | — | US | disclosed |
| EP-0664792-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO. INC. (US) | 1995-08-02 | — | — | EP | disclosed |
| WO-1994008962-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1994-04-28 | — | — | WO | disclosed |