Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.52 |
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL774317 | 0.89 | ADORA3 (0.72) | ADORA3ALDH1A1CYP3A4MAOAALOX5 | |
| SCHEMBL4287360 | 0.87 | ALDH1A1 (0.55) | ADORA3ALDH1A1CYP3A4MAOAALOX5 | |
| SCHEMBL28066116 | 0.86 | MKNK2 (0.63) | ADORA3ALDH1A1CYP3A4MAOAALOX5 | |
| SCHEMBL28570505 | 0.84 | ALDH1A1 (0.60) | ADORA3ALDH1A1CYP3A4MAOAALOX5 | |
| SCHEMBL10646756 | 0.83 | ADORA3 (0.60) | ADORA3ALDH1A1CYP3A4MAOAALOX5 | |
| SCHEMBL28566855 | 0.82 | ALDH1A1 (0.57) | ADORA3ALDH1A1CYP3A4ALOX5MEN1 | |
| SCHEMBL28329557 | 0.82 | ADORA3 (0.53) | ADORA3ALDH1A1CYP3A4MAOAALOX5 | |
| SCHEMBL27891740 | 0.78 | MKNK2 (0.74) | ADORA3ALDH1A1CYP3A4MAOAALOX5 | |
| SCHEMBL28647308 | 0.78 | ABCB1 (0.81) | ADORA3ALOX5MEN1KMT2AABCB1 | |
| SCHEMBL28040768 | 0.78 | MAPT (0.63) | ADORA3ALDH1A1CYP3A4MAOAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138165-B2 | Chromones and chromone derivatives and uses thereof | JENKEN BIOSCIENCES, INC. (US) | 2012-03-20 | — | — | US | claimed |
| EP-1556031-A4 | CHROMONES AND CHROMONE DERIVATIVES AND USES THEREOF | JENKEN BIOSCIENCES INC (US) | 2009-03-25 | — | — | EP | claimed |
| US-20060142211-A1 | Chromones and chromone derivatives and uses thereof | TAIWANJ PHARMACEUTICALS CO., LTD. (TW) | 2006-06-29 | — | — | US | claimed |
| CN-1705473-A | Chromones and chromone derivatives and uses thereof | JENKEN BIOSCIENCES INC (US) | 2005-12-07 | — | — | CN | claimed |
| EP-1556031-A2 | CHROMONES AND CHROMONE DERIVATIVES AND USES THEREOF | Jenken Bioscience, Inc. (US) | 2005-07-27 | — | — | EP | claimed |
| WO-2004037193-A2 | CHROMONES AND CHROMONE DERIVATIVES AND USES THEREOF | JENKEN BIOSCIENCES, INC. (US) | 2004-05-06 | — | — | WO | claimed |
| US-8138165-B2 | Chromones and chromone derivatives and uses thereof | JENKEN BIOSCIENCES, INC. (US) | 2012-03-20 | — | — | US | disclosed |
| EP-1556031-A4 | CHROMONES AND CHROMONE DERIVATIVES AND USES THEREOF | JENKEN BIOSCIENCES INC (US) | 2009-03-25 | — | — | EP | disclosed |
| US-20060142211-A1 | Chromones and chromone derivatives and uses thereof | TAIWANJ PHARMACEUTICALS CO., LTD. (TW) | 2006-06-29 | — | — | US | disclosed |
| CN-1705473-A | Chromones and chromone derivatives and uses thereof | JENKEN BIOSCIENCES INC (US) | 2005-12-07 | — | — | CN | disclosed |
| EP-1556031-A2 | CHROMONES AND CHROMONE DERIVATIVES AND USES THEREOF | Jenken Bioscience, Inc. (US) | 2005-07-27 | — | — | EP | disclosed |
| WO-2004037193-A2 | CHROMONES AND CHROMONE DERIVATIVES AND USES THEREOF | JENKEN BIOSCIENCES, INC. (US) | 2004-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142211-A1 | Chromones and chromone derivatives and uses thereof | PROC, HMGB1, PYCARD | ADORA3 1975/4885ALDH1A1 3225/4885CYP3A4 89/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.