Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.30 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15592685 | 0.73 | LMNA (0.51) | LMNAALDH1A1KDM4EADORA3PKM | |
| SCHEMBL19797901 | 0.72 | APOBEC3A (0.41) | LMNAALDH1A1KDM4EADORA3PKM | |
| SCHEMBL25562761 | 0.66 | APOBEC3A (0.39) | LMNAALDH1A1 | |
| SCHEMBL15601778 | 0.64 | LMNA (0.46) | LMNAALDH1A1KDM4EADORA3PKM | |
| SCHEMBL12123617 | 0.64 | ALDH1A1 (0.39) | LMNAALDH1A1 | |
| SCHEMBL7375007 | 0.64 | APOBEC3A (0.38) | LMNAALDH1A1ADORA2B | |
| SCHEMBL7378481 | 0.63 | KDM4E (0.42) | LMNAALDH1A1KDM4EPIM3PIM2 | |
| SCHEMBL7379327 | 0.62 | MPO (0.34) | — | |
| SCHEMBL23930918 | 0.62 | GABRA1 (0.36) | ALDH1A1 | |
| SCHEMBL7375008 | 0.62 | PDE4A (0.35) | LMNAKDM4EADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165500-A1 | AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES,TNF-ALPHA,AND AGGRECANASE | Du Pont Pharmaceuticals Company (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059874-A1 | NOVEL AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES, TNF-α, AND AGGRECANASE | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-10-12 | — | — | WO | disclosed |