Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR132 | Q9UNW8 | 2/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 4/20 | 0.39 |
| ▸ | CA1 | P00915 | 3/20 | 0.39 |
| ▸ | MEP1B | Q16820 | 2/20 | 0.39 |
| ▸ | ACE | P12821 | 2/20 | 0.39 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.38 |
| ▸ | ITGAV | P06756 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.38 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7376324 | 0.82 | GPR132 (0.49) | GPR132MMP9CA2CA1ACE | |
| SCHEMBL7376317 | 0.82 | GPR132 (0.49) | GPR132MMP9CA2CA1ACE | |
| SCHEMBL6775970 | 0.82 | GPR132 (0.49) | GPR132CA2CA1ACEITGB3 | |
| SCHEMBL7468481 | 0.79 | SIGMAR1 (0.51) | MMP9ACEMMENAALAD2 | |
| SCHEMBL17944509 | 0.79 | SIGMAR1 (0.51) | MMP9ACEMMENAALAD2 | |
| SCHEMBL7373859 | 0.78 | GPR132 (0.53) | GPR132CA2CA1ACEMME | |
| SCHEMBL6779399 | 0.78 | GPR132 (0.47) | GPR132 | |
| SCHEMBL7823171 | 0.77 | ITGB3 (0.50) | GPR132ACEMMEITGB3ITGB1 | |
| SCHEMBL7377643 | 0.77 | F10 (0.46) | GPR132ITGB3ITGA2B | |
| SCHEMBL8430799 | 0.77 | SIRT2 (0.41) | GPR132 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891325-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1999-01-20 | — | — | EP | claimed |
| WO-1997036859-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | claimed |