Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.38 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.38 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.37 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | ITGAV | P06756 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7375119 | 0.83 | FFAR1 (0.47) | AKR1C3PTGER3ITGB3ITGA2BFFAR1 | |
| SCHEMBL7520432 | 0.82 | AKR1C3 (0.44) | AKR1C3AGTR1RAB9AITGB3ITGA2B | |
| SCHEMBL7377645 | 0.78 | BCHE (0.49) | HDAC6 | |
| SCHEMBL7380190 | 0.78 | KCNK3 (0.46) | KCNK3KCNK9ITGB3ITGA2BITGAV | |
| SCHEMBL8369251 | 0.77 | CASP3 (0.52) | KDM4EKCNK3KCNK9 | |
| SCHEMBL8432521 | 0.76 | ABCB11 (0.41) | PTGER1PTGER4PTGER3PTGER2SIRT1 | |
| SCHEMBL7380359 | 0.76 | KCNK3 (0.46) | RAB9AKCNK3KCNK9ITGB3ITGA2B | |
| SCHEMBL7373860 | 0.75 | PTGER1 (0.44) | PTGER1PTGER4PTGER3PTGER2KCNK3 | |
| SCHEMBL7380550 | 0.74 | ITGB3 (0.43) | KDM4EKCNK3KCNK9ITGB3ITGA2B | |
| SCHEMBL8429208 | 0.74 | SIRT1 (0.37) | PTGER1PTGER4PTGER3PTGER2SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891325-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1999-01-20 | — | — | EP | claimed |
| WO-1997036859-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | claimed |