Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 7/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7372548 | 0.84 | RORC (0.41) | RORCMAPTSMN1; SMN2TP53NOTUM | |
| SCHEMBL7376845 | 0.77 | NOTUM (0.48) | MAPTSMN1; SMN2NOTUMMEN1NPC1 | |
| SCHEMBL7379131 | 0.74 | RAB9A (0.47) | MAPTTP53NOTUMMEN1NPC1 | |
| SCHEMBL30020309 | 0.74 | NOTUM (0.51) | MAPTSMN1; SMN2NOTUMMEN1NPC1 | |
| SCHEMBL7378474 | 0.73 | F2R (0.36) | NOTUMMEN1KMT2A | |
| SCHEMBL7374152 | 0.71 | ALDH1A1 (0.46) | MAPTSMN1; SMN2NOTUMMEN1NPC1 | |
| SCHEMBL7375026 | 0.71 | RAB9A (0.38) | SMN1; SMN2NOTUMMEN1NPC1RAB9A | |
| SCHEMBL7380618 | 0.70 | ADORA2A (0.34) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL3141291 | 0.67 | ALDH1A1 (0.48) | MAPTSMN1; SMN2TP53NOTUMMEN1 | |
| SCHEMBL7371967 | 0.67 | GABRG2 (0.35) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997008150-A1 | SUBSTITUTED CYCLIC UREAS AND DERIVATIVES THEREOF USEFUL AS RETROVIRAL PROTEASE INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-03-06 | — | — | WO | claimed |
| US-5763469-A | Substituted cyclic ureas and derivatives thereof useful as retroviral protease inhibitors | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-06-09 | — | — | US | disclosed |
| WO-1997008150-A1 | SUBSTITUTED CYCLIC UREAS AND DERIVATIVES THEREOF USEFUL AS RETROVIRAL PROTEASE INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-03-06 | — | — | WO | disclosed |