Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2R | P25116 | 11/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.33 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7375026 | 0.83 | RAB9A (0.38) | F2RNOTUMKMT2AUCHL1USP30 | |
| SCHEMBL7376845 | 0.77 | NOTUM (0.48) | NOTUMKMT2AMEN1 | |
| SCHEMBL7379131 | 0.74 | RAB9A (0.47) | NOTUMKMT2AMEN1HSD17B1HSD17B2 | |
| SCHEMBL7376902 | 0.73 | RORC (0.38) | NOTUMKMT2AMEN1 | |
| SCHEMBL7372548 | 0.72 | RORC (0.41) | NOTUMKMT2AMEN1 | |
| SCHEMBL7374152 | 0.71 | ALDH1A1 (0.46) | NOTUMKMT2AMEN1HSD17B1HSD17B2 | |
| SCHEMBL7377663 | 0.70 | LMNA (0.32) | KMT2A | |
| SCHEMBL3141291 | 0.67 | ALDH1A1 (0.48) | NOTUMKMT2AMEN1 | |
| SCHEMBL7377289 | 0.67 | KMT2A (0.35) | KMT2A | |
| SCHEMBL27690834 | 0.66 | CYP2E1 (0.58) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997008150-A1 | SUBSTITUTED CYCLIC UREAS AND DERIVATIVES THEREOF USEFUL AS RETROVIRAL PROTEASE INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-03-06 | — | — | WO | claimed |
| US-5763469-A | Substituted cyclic ureas and derivatives thereof useful as retroviral protease inhibitors | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-06-09 | — | — | US | disclosed |
| WO-1997008150-A1 | SUBSTITUTED CYCLIC UREAS AND DERIVATIVES THEREOF USEFUL AS RETROVIRAL PROTEASE INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-03-06 | — | — | WO | disclosed |