Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 8/20 | 0.58 |
| ▸ | CTSB | P07858 | 3/20 | 0.58 |
| ▸ | CTSD | P07339 | 1/20 | 0.49 |
| ▸ | LNPEP | Q9UIQ6 | 5/20 | 0.48 |
| ▸ | ERAP2 | Q6P179 | 3/20 | 0.48 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 2/20 | 0.46 |
| ▸ | CTSL | P07711 | 2/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29536591 | 0.93 | CTSK (0.61) | CTSKCTSBCTSDLNPEPERAP2 | |
| Trifluoroacetic Acid SCHEMBL7371398 | 0.89 | CTSK (0.50) | CTSKCTSBCTSSCTSLSCN9A | |
| Trifluoroacetic Acid SCHEMBL27697116 | 0.84 | ANPEP (0.49) | CTSKCTSBCTSSCTSL | |
| SCHEMBL29832541 | 0.84 | CTSB (0.56) | CTSKCTSBCTSDLNPEPERAP2 | |
| SCHEMBL29770321 | 0.84 | CTSB (0.56) | CTSKCTSBCTSDLNPEPERAP2 | |
| Trifluoroacetic Acid SCHEMBL9439517 | 0.84 | PSMB1 (0.52) | CTSKCTSBCTSSCTSL | |
| SCHEMBL9099075 | 0.83 | CTSB (0.51) | CTSKCTSBCTSDLNPEPERAP2 | |
| SCHEMBL9099082 | 0.83 | CTSK (0.51) | CTSKCTSBCTSDLNPEPERAP2 | |
| Trifluoroacetic Acid SCHEMBL9320615 | 0.82 | CTSK (0.58) | CTSKCTSBCTSDERAP2ERAP1 | |
| Trifluoroacetic Acid SCHEMBL10443782 | 0.82 | CTSK (0.54) | CTSKCTSBCTSSCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0672648-B1 | Threo (2R,3S)-3-amino-2-hydroxypentanoic acid and threo (2R,3S)-3-(p-methoxy-benzyloxycarbonyl/FMOC) amino-2-hydroxy-pentanoic acid | ZAIDAN HOJIN BISEIBUTSU (JP) | 1998-09-23 | — | — | EP | disclosed |
| EP-0468339-B1 | Alpha-keto-amide derivatives having protease inhibiting activity | NIPPON KAYAKU KK (JP) | 1997-04-09 | — | — | EP | disclosed |
| EP-0672648-A1 | Threo-3-amino-2-hydroxypentanoic acid and threo (2R,3S), (2S,3R)-3-(p-methoxy-benzyloxycarbonyl) amino-2-hydroxy-pentanoic acid | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1995-09-20 | — | — | EP | disclosed |
| US-5359138-A | Endopeptidase inhibitors for treatment of amnesia and autoimmune diseases | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1994-10-25 | — | — | US | disclosed |
| US-5162500-A | POSTSTATIN AND RELATED COMPOUNDS OR SALTS THEREOF | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1992-11-10 | — | — | US | disclosed |
| EP-0423358-A1 | POSTOSTATIN AND RELATED COMPOUND THEREOF, OR THEIR SALTS | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1991-04-24 | — | — | EP | disclosed |