Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31387673 | 0.79 | HTR3A (0.58) | HTR3AKCNH2 | |
| SCHEMBL7289440 | 0.79 | HTR3A (0.58) | HTR3AKCNH2 | |
| Hydrochloric Acid SCHEMBL7289083 | 0.79 | HTR3A (0.57) | HTR3AKCNH2 | |
| Maleic Acid SCHEMBL10401263 | 0.77 | PKM (0.48) | — | |
| SCHEMBL7375497 | 0.75 | HTR3A (0.50) | HTR3AKCNH2 | |
| Fumaric Acid SCHEMBL7270720 | 0.75 | HTR2A (0.48) | HTR3AKCNH2 | |
| Fumaric Acid SCHEMBL7270730 | 0.75 | HTR2A (0.48) | HTR3AKCNH2 | |
| Fumaric Acid SCHEMBL7270255 | 0.73 | — | — | |
| Fumaric Acid SCHEMBL7270242 | 0.73 | — | — | |
| SCHEMBL8939964 | 0.70 | PKM (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0313393-A2 | Benzoxazine compounds and pharmaceutical use thereof | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1989-04-26 | — | — | EP | disclosed |