Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.34 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5799161 | 0.73 | EGFR (0.41) | KMT2AL3MBTL1EGFRALDH1A1PKM | |
| SCHEMBL7600994 | 0.72 | KMT2A (0.47) | KMT2AMEN1POLBL3MBTL1PABPC1 | |
| SCHEMBL17699703 | 0.71 | EGFR (0.41) | KMT2AMEN1POLBL3MBTL1EGFR | |
| SCHEMBL21975440 | 0.70 | GPR3 (0.44) | ALDH1A1CNR2 | |
| SCHEMBL23563223 | 0.69 | KDM4E (0.39) | KMT2AMEN1ALDH1A1PKMCNR2 | |
| SCHEMBL28207997 | 0.69 | MEN1 (0.45) | KMT2AMEN1L3MBTL1ALDH1A1MCL1 | |
| SCHEMBL11846322 | 0.68 | THRB (0.54) | CA12CA1CA2CA9KMT2A | |
| SCHEMBL3580870 | 0.67 | POLB (0.44) | KMT2APOLBALDH1A1CNR2 | |
| SCHEMBL6272437 | 0.66 | PRNP (0.47) | CA12CA1CA2CA9KMT2A | |
| SCHEMBL3564843 | 0.66 | ALDH1A1 (0.47) | KMT2AMEN1L3MBTL1PABPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000063-B1 | 4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOLE-1-ACETAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY | SANOFI SYNTHELABO (FR) | 2002-10-23 | — | — | EP | disclosed |
| EP-1000063-A1 | 4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO 4,5-$i(b)]-INDOLE-1-ACETAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY | SANOFI-SYNTHELABO (FR) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999006406-A1 | 4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]-INDOLE-1-ACETAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY | SANOFI-SYNTHELABO (FR) | 1999-02-11 | — | — | WO | disclosed |