Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 3/20 | 0.39 |
| ▸ | GRK5 | P34947 | 2/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | LTK | P29376 | 1/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | PRKX | P51817 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2804664 | 0.78 | RET (0.44) | RETGRK5TYRO3DYRK1BCHEK1 | |
| SCHEMBL29689422 | 0.75 | RET (0.46) | RETGRK5TYRO3DYRK1BCHEK1 | |
| SCHEMBL23138147 | 0.71 | MAPK1 (0.36) | KMT2ALMNAPOLBMAPK1BLM | |
| SCHEMBL9179277 | 0.67 | RET (0.53) | RETGRK5TYRO3DYRK1BCHEK1 | |
| SCHEMBL2803756 | 0.67 | RET (0.44) | RETGRK5TYRO3DYRK1BCHEK1 | |
| SCHEMBL2443752 | 0.65 | GAA (0.46) | CHEK1LIMK1DYRK1ACLK4KMT2A | |
| SCHEMBL9442809 | 0.65 | CA12 (0.40) | RETGRK5TYRO3DYRK1BCHEK1 | |
| SCHEMBL29689072 | 0.65 | CA12 (0.39) | RETGRK5TYRO3DYRK1BCHEK1 | |
| SCHEMBL29689272 | 0.65 | CA12 (0.39) | RETGRK5TYRO3DYRK1BCHEK1 | |
| SCHEMBL3259642 | 0.63 | CA1 (0.50) | RETGRK5TYRO3DYRK1BCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0550111-A1 | 2-Saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and pharmaceutical compositions containing them | STERLING WINTHROP INC. (US) | 1993-07-07 | — | — | EP | disclosed |
| EP-0550112-A1 | 2-Saccharinylmethyl aryl and aryloxy acetates useful as proteolytic enzyme inhibitors and pharmaceutical compositions contaning them | STERLING WINTHROP INC. (US) | 1993-07-07 | — | — | EP | disclosed |