Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7393385 | 0.91 | SIGMAR1 (0.48) | TSHRLMNAALDH1A1MAPTGRM2 | |
| SCHEMBL5530617 | 0.86 | SIGMAR1 (0.45) | SIGMAR1 | |
| SCHEMBL7390705 | 0.85 | SIGMAR1 (0.42) | SIGMAR1 | |
| SCHEMBL7473955 | 0.85 | MGLL (0.53) | SIGMAR1 | |
| SCHEMBL7388548 | 0.85 | MAPT (0.45) | TSHRLMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7387950 | 0.85 | THRB (0.45) | TSHRSMN1; SMN2SIGMAR1HTT | |
| SCHEMBL7388767 | 0.85 | SIGMAR1 (0.45) | SIGMAR1 | |
| SCHEMBL7390909 | 0.84 | SMYD3 (0.46) | SIGMAR1 | |
| SCHEMBL5530623 | 0.84 | SIGMAR1 (0.45) | SIGMAR1 | |
| SCHEMBL7386638 | 0.83 | THRB (0.47) | LMNAMAPTSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056743-A1 | BENZAMINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999031092-A1 | BENZAMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 1999-06-24 | — | — | WO | disclosed |