Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.36 |
| ▸ | PIK3CD known ✓ | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CG known ✓ | P48736 | 1/20 | 0.35 |
| ▸ | HRH3 known ✓ | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | CCR5 known ✓ | P51681 | 1/20 | 0.34 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.34 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 8/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 8/20 | 0.36 |
| ▸ | NMT1 | P30419 | 1/20 | 0.36 |
| ▸ | NPY2R | P49146 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL7392185 | 1.00 | HCRTR1 (0.36) | HCRTR1HCRTR2KMT2ANMT1PIK3CD | |
| SCHEMBL7399277 | 0.95 | KMT2A (0.39) | HCRTR1HCRTR2KMT2ANMT1PIK3CD | |
| Fumaric Acid SCHEMBL7400191 | 0.85 | ACKR3 (0.40) | HCRTR1HCRTR2KMT2APIK3CDPIK3CG | |
| Maleic Acid SCHEMBL7400186 | 0.85 | ACKR3 (0.40) | HCRTR1HCRTR2KMT2APIK3CDPIK3CG | |
| Fumaric Acid SCHEMBL7400733 | 0.83 | POLB (0.36) | HCRTR1HCRTR2KMT2APIK3CDPIK3CG | |
| Maleic Acid SCHEMBL7400730 | 0.83 | POLB (0.36) | HCRTR1HCRTR2KMT2APIK3CDPIK3CG | |
| Maleic Acid SCHEMBL7399487 | 0.82 | KDM1A (0.38) | HCRTR1HCRTR2KMT2A | |
| SCHEMBL7397799 | 0.82 | ACHE (0.46) | — | |
| Fumaric Acid SCHEMBL7399492 | 0.81 | HCRTR1 (0.33) | HCRTR1HCRTR2KMT2AOPRK1KCNH2 | |
| Maleic Acid SCHEMBL7399489 | 0.81 | HCRTR1 (0.33) | HCRTR1HCRTR2KMT2AOPRK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0972773-A1 | 2-Oxadiazolyl- or 2-thiadiazolyl-phenylcarbamate and -phenylurea derivatives, their preparation and their use as intermediates | GLAXO GROUP LIMITED (GB) | 2000-01-19 | — | — | EP | disclosed |
| US-5618827-A | TREATING GASTROINTESTINAL, URINARY, CARDIOVASCULAR, CENTRAL NERVOUS SYTEM DISORDERS | GLAXO GROUP LIMITED (GB) | 1997-04-08 | — | — | US | disclosed |
| EP-0640081-A1 | SUBSTITUTED PHENYLCARBAMATES AND PHENYLUREAS, THEIR PREPARATION AND THEIR USE AS 5-HT ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 1995-03-01 | — | — | EP | disclosed |
| WO-1993020071-A1 | SUBSTITUTED PHENYLCARBAMATES AND PHENYLUREAS, THEIR PREPARATION AND THEIR USE AS 5-HT ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 1993-10-14 | — | — | WO | disclosed |