Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.60 |
| ▸ | DRD3 | P35462 | 4/20 | 0.60 |
| ▸ | HTR1A | P08908 | 3/20 | 0.60 |
| ▸ | HTR2A | P28223 | 3/20 | 0.60 |
| ▸ | HTR7 | P34969 | 3/20 | 0.60 |
| ▸ | HTR2B | P41595 | 3/20 | 0.60 |
| ▸ | HRH1 | P35367 | 2/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5182996 | 0.84 | ALDH1A1 (0.76) | DRD2DRD3HTR1AHTR2AHTR7 | |
| SCHEMBL7390493 | 0.84 | MAPT (0.61) | DRD2DRD3HTR1AHTR2AHTR7 | |
| SCHEMBL7390501 | 0.84 | MAPT (0.61) | DRD2DRD3HTR1AHTR2AHTR7 | |
| SCHEMBL7386508 | 0.84 | MAPT (0.61) | DRD2DRD3HTR1AHTR2AHTR7 | |
| SCHEMBL7390405 | 0.83 | HTR1A (0.55) | DRD2DRD3HTR1AHTR2AHTR7 | |
| SCHEMBL2834503 | 0.83 | ALDH1A1 (0.79) | DRD2DRD3HTR1AHTR2AHTR7 | |
| SCHEMBL7385393 | 0.82 | DRD2 (0.58) | DRD2DRD3HTR1AHTR2AHTR7 | |
| SCHEMBL11077909 | 0.82 | DRD2 (0.58) | DRD2DRD3HTR1AHTR2AHTR7 | |
| SCHEMBL7393089 | 0.81 | ADRA1D (0.62) | DRD2HTR2AMAPTL3MBTL1LMNA | |
| SCHEMBL13089316 | 0.79 | ALDH1A1 (0.66) | DRD2HTR7ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5864039-A | THERAPEUTIC TREATMENT OF VARIOUS GASTROINTESTINAL DISEASES, CENTRAL NERVOUS DISORDERS, CARDIOVASCULAR DISORDERS, URINARY DISEASES, UROGENITAL DISORDERS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1999-01-26 | — | — | US | disclosed |
| EP-0873990-A1 | BENZOIC ACID COMPOUNDS AND MEDICINAL USE THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-10-28 | — | — | EP | disclosed |