Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6443240 | 0.97 | ALDH1A1 (0.32) | ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL6200427 | 0.83 | USP2 (0.42) | ALDH1A1KDM4EMEN1MAPK1KMT2A | |
| SCHEMBL6446771 | 0.78 | PDE5A (0.36) | MEN1KMT2A | |
| SCHEMBL6441740 | 0.77 | CTDSP1 (0.36) | ALDH1A1MEN1MAPK1KMT2A | |
| SCHEMBL6442195 | 0.74 | SMN1; SMN2 (0.39) | ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL5827229 | 0.72 | ADRA1D (0.40) | ALDH1A1KDM4EMEN1MAPK1KMT2A | |
| SCHEMBL6442971 | 0.70 | SMN1; SMN2 (0.40) | ALDH1A1MEN1KMT2A | |
| SCHEMBL6442051 | 0.69 | PTGDR2 (0.46) | ALDH1A1KDM4EHPGDMEN1MAPK1 | |
| SCHEMBL6441689 | 0.68 | KDM4E (0.37) | ALDH1A1KDM4EHSD17B10MEN1KMT2A | |
| SCHEMBL6450553 | 0.68 | PDE5A (0.39) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1073658-A1 | PYRAZOLOPYRIMIDINONE CGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER INC. (US) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999054333-A1 | PYRAZOLOPYRIMIDINONE CGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER INC. (US) | 1999-10-28 | — | — | WO | disclosed |