Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7547811 | 0.84 | LMNA (0.45) | HPGDLMNAPKMKMT2AALDH1A1 | |
| SCHEMBL6427941 | 0.80 | LAP3 (0.52) | HPGDLMNAPKMKMT2AALDH1A1 | |
| SCHEMBL8577651 | 0.73 | MEN1 (0.39) | HPGDLMNAPKMKMT2AALDH1A1 | |
| SCHEMBL4394350 | 0.72 | CASR (0.53) | HPGDLMNAPKMKMT2AALDH1A1 | |
| SCHEMBL10778356 | 0.71 | LPAR1 (0.52) | LMNAPKMKMT2AALDH1A1MEN1 | |
| SCHEMBL28808203 | 0.71 | HPGD (1.00) | HPGDLMNAPKMKMT2AALDH1A1 | |
| SCHEMBL8502371 | 0.70 | OPRK1 (0.48) | KMT2AALDH1A1MEN1TSHROPRM1 | |
| SCHEMBL8773812 | 0.70 | SMN1; SMN2 (0.44) | SMN1; SMN2 | |
| SCHEMBL10076985 | 0.70 | TSHR (0.51) | HPGDLMNAPKMKMT2AALDH1A1 | |
| Bicarbonate SCHEMBL27892668 | 0.69 | TSHR (0.59) | HPGDLMNAPKMKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0735019-A2 | Retroviral protease inhibitors | MONSANTO COMPANY (US) | 1996-10-02 | — | — | EP | disclosed |
| EP-0731088-A2 | Retroviral protease inhibitors | MONSANTO COMPANY (US) | 1996-09-11 | — | — | EP | disclosed |
| US-5482947-A | ENZYME INHIBITORS FOR HIV PROTEASE INHIBITION FROM UREA OR THIOUREA COMPOUNDS | TALLEY JOHN J (US) | 1996-01-09 | — | — | US | disclosed |
| WO-1993023368-A1 | UREA-CONTAINING HYDROXYETHYLAMINE COMPOUNDS AS RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 1993-11-25 | — | — | WO | disclosed |
| EP-0558603-A1 | RETROVIRAL PROTEASE INHIBITORS | MONSANTO COMPANY (US) | 1993-09-08 | — | — | EP | disclosed |
| WO-1992008688-A1 | RETROVIRAL PROTEASE INHIBITORS | MONSANTO COMPANY (US) | 1992-05-29 | — | — | WO | disclosed |