Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.49 |
| ▸ | CTSD | P07339 | 2/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 14/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 14/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 14/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 14/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 14/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 14/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | CTSS | P25774 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8605875 | 0.90 | PSEN1 (0.56) | RENCTSDPSEN1PSEN2APH1B | |
| SCHEMBL7405000 | 0.90 | REN (0.45) | RENCTSDPSEN1PSEN2APH1B | |
| SCHEMBL6431948 | 0.89 | CTSB (0.55) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6431945 | 0.89 | CTSB (0.55) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7402232 | 0.88 | CTSD (0.46) | RENCTSDPSEN1PSEN2APH1B | |
| SCHEMBL7394330 | 0.86 | CTSD (0.49) | RENCTSDPSEN1PSEN2APH1B | |
| SCHEMBL8664644 | 0.86 | CTSD (0.48) | RENCTSDPSEN1PSEN2APH1B | |
| SCHEMBL7403620 | 0.85 | CTSD (0.47) | RENCTSDPSEN1PSEN2APH1B | |
| SCHEMBL7396675 | 0.85 | CTSD (0.47) | RENCTSDPSEN1PSEN2APH1B | |
| SCHEMBL7401649 | 0.84 | CTRB1 (0.48) | RENLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5750648-A | HUMAN IMMUNODEFICIENCY VIRUS | G.D. SEARLE & CO. (US) | 1998-05-12 | — | — | US | claimed |
| WO-1995006061-A1 | RETROVIRAL PROTEASE INHIBITORS AND COMBINATIONS THEREOF | G.D. SEARLE & CO. (US) | 1995-03-02 | — | — | WO | claimed |