Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 6/20 | 0.43 |
| ▸ | TPH2 | Q8IWU9 | 6/20 | 0.43 |
| ▸ | SCARB1 | Q8WTV0 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7404113 | 0.84 | SCARB1 (0.46) | TPH1TPH2SCARB1ALDH1A1GRIN1 | |
| SCHEMBL7406962 | 0.75 | F10 (0.48) | ALDH1A1 | |
| SCHEMBL5864478 | 0.70 | ALDH1A1 (0.64) | ALDH1A1PDE10AGAAMAPT | |
| SCHEMBL7401476 | 0.70 | HSD17B10 (0.45) | ALDH1A1GRIN1GRIN2BPDE10AMAPT | |
| SCHEMBL12202119 | 0.68 | ALDH1A1 (0.68) | ALDH1A1PDE10AMAPT | |
| SCHEMBL7401472 | 0.67 | MMP2 (0.47) | ALDH1A1GRIN1GRIN2BPDE10A | |
| SCHEMBL7265526 | 0.66 | GAA (0.69) | GRIN1GRIN2BEGFRGAAHPGD | |
| SCHEMBL7407177 | 0.66 | F10 (0.64) | — | |
| SCHEMBL7407685 | 0.65 | F10 (0.48) | TPH1TPH2ALDH1A1GAAMAPT | |
| SCHEMBL7477456 | 0.65 | GLP1R (0.44) | ALDH1A1GRIN1GRIN2BMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999026932-A1 | BY AMIDINO GROUP SUBSTITUTED HETEROCYCLIC DERIVATIVES AND THEIR USE AS ANTICOAGULANTS | AXYS PHARMACEUTICALS, INC. (US) | 1999-06-03 | — | — | WO | disclosed |