SCHEMBL740264

SCHEMBL740264

CC(=NC#N)N(Cc1ccc(Cl)nc1)CC(F)F

nearest known ligand 0.66

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.36
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
ATM Q13315 1/20 0.35
CHRNB2 P17787 1/20 0.35
CHRNA4 P43681 1/20 0.35
CHRNA7 P36544 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
AR P10275 1/20 0.33
POLB P06746 1/20 0.32
KDM4E B2RXH2 1/20 0.32
GAA P10253 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
LMNA P02545 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30195631 1.00 ALDH1A1 (0.36) ALDH1A1MEN1KMT2AATMCHRNB2
SCHEMBL740263 1.00 ALDH1A1 (0.36) ALDH1A1MEN1KMT2AATMCHRNB2
SCHEMBL14304158 0.85 ALDH1A1 (0.40) ALDH1A1MEN1KMT2AATMCHRNB2
SCHEMBL764579 0.85 ALDH1A1 (0.40) ALDH1A1MEN1KMT2AATMCHRNB2
SCHEMBL10028746 0.85 ALDH1A1 (0.40) ALDH1A1MEN1KMT2AATMCHRNB2
SCHEMBL16803412 0.84 ALDH1A1 (0.37) ALDH1A1MEN1KMT2AATMCHRNB2
SCHEMBL19846471 0.84 TKT (0.34)
SCHEMBL738903 0.82 ALDH1A1 (0.36) ALDH1A1MEN1KMT2AATMCHRNB2
SCHEMBL738902 0.82 ALDH1A1 (0.36) ALDH1A1MEN1KMT2AATMCHRNB2
SCHEMBL737430 0.81 ALDH1A1 (0.35) ALDH1A1MEN1KMT2AATMCHRNB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 255 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3010893-B1 ARYLSULFIDE AND ARYLSULFOXIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES BAYER CROPSCIENCE AG (DE) 2019-10-02 EP claimed
US-20190159451-A1 ACTIVE COMPOUND COMBINATIONS AND METHODS TO PROTECT THE PROPAGATION MATERIAL OF PLANTS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2019-05-30 US claimed
EP-3010889-B1 ARYLSULFIDE AND ARYLSULFOXIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES BAYER CROPSCIENCE AG (DE) 2018-10-03 EP claimed
EP-2793578-B1 N-ARYLAMIDINE-SUBSTITUTED TRIFLUOROETHYLSULFIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES BAYER CROPSCIENCE AG (DE) 2018-06-06 EP claimed
EP-2925142-B1 COMPOSITION COMPRISING A BIOLOGICAL CONTROL AGENT AND AN INSECTICIDE BAYER CROPSCIENCE AG (DE) 2018-01-31 EP claimed
US-9867377-B2 Composition comprising a biological control agent and an insecticide BAYER CROPSCIENCE AG (DE) 2018-01-16 US claimed
US-20170265479-A1 COMPOSITION COMPRISING BIOLOGICAL CONTROL AGENTS BAYER CROPSCIENCE AG (DE) 2017-09-21 US claimed
US-9693565-B2 Composition comprising biological control agents BAYER CROPSCIENCE AG (DE) 2017-07-04 US claimed
US-9642363-B2 N-arylamidine-substituted trifluoroethyl sulfide derivatives as acaricides and insecticides BAYER CROPSCIENCE AG (DE) 2017-05-09 US claimed
US-20160262401-A1 COMPOSITIONS COMPRISING A BIOLOGICAL CONTROL AGENT AND AN INSECTICIDE BAYER CROPSCIENCE AG (DE) 2016-09-15 US claimed
US-20160000091-A1 COMPOSITION COMPRISING A BIOLOGICAL CONTROL AGENT AND AN INSECTICIDE BAYER CROPSCIENCE AG (DE) 2016-01-07 US claimed
US-20150344499-A1 ARYL SULFIDE DERIVATIVES AND ARYL SULFOXIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES BAYER CROPSCIENCE AG (DE) 2015-12-03 US claimed
US-20150305348-A1 COMPOSITION COMPRISING BIOLOGICAL CONTROL AGENTS BAYER CROPSCIENCE AG (DE) 2015-10-29 US claimed
US-20150296804-A1 COMPOSITION COMPRISING BIOLOGICAL CONTROL AGENTS DANSTAR FERMENT AG (CH) 2015-10-22 US claimed
US-20150296803-A1 COMPOSITION COMPRISING A BIOLOGICAL CONTROL AGENT AND AN INSECTICIDE BAYER CROPSCIENCE AG (DE) 2015-10-22 US claimed
US-20150289518-A1 COMPOSITION COMPRISING A BIOLOGICAL CONTROL AGENT AND AN INSECTICIDE BAYER CROPSCIENCE AG (DE) 2015-10-15 US claimed
US-20150189882-A1 ACTIVE INGREDIENT COMBINATIONS HAVING INSECTICIDAL AND ACARICIDAL PROPERTIES BAYER INTELLECTUAL PROPERTY GMBH 2015-07-09 US claimed
US-20150148230-A1 COMPOSITIONS COMPRISING A BIOLOGICAL CONTROL AGENT AND AN INSECTICIDE BAYER CROPSCIENCE AG (DE) 2015-05-28 US claimed
US-20140315898-A1 N-ARYLAMIDINE-SUBSTITUTED TRIFLUOROETHYL SULFIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES BAYER CROPSCIENCE AG (DE) 2014-10-23 US claimed
EP-2604118-A1 Active ingredient combinations having insecticidal and acaricidal properties Bayer CropScience AG (DE) 2013-06-19 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140315898-A1 N-ARYLAMIDINE-SUBSTITUTED TRIFLUOROETHYL SULFIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES AFF4, ARSA, AFF1 ALDH1A1 1348/4885MEN1 4026/4885KMT2A 2592/4885
US-20190159451-A1 ACTIVE COMPOUND COMBINATIONS AND METHODS TO PROTECT THE PROPAGATION MATERIAL OF PLANTS BROX, CAT, MPG ALDH1A1 3331/4885MEN1 1143/4885KMT2A 3113/4885
US-20150189882-A1 ACTIVE INGREDIENT COMBINATIONS HAVING INSECTICIDAL AND ACARICIDAL PROPERTIES ACHE, AADAC, ACAT2 ALDH1A1 567/4885MEN1 2539/4885KMT2A 2811/4885
US-20150148230-A1 COMPOSITIONS COMPRISING A BIOLOGICAL CONTROL AGENT AND AN INSECTICIDE DDT, ACHE, BROX ALDH1A1 2817/4885MEN1 3142/4885KMT2A 1203/4885
US-20160262401-A1 COMPOSITIONS COMPRISING A BIOLOGICAL CONTROL AGENT AND AN INSECTICIDE O60361, GAP43, BMP4 ALDH1A1 3353/4885MEN1 2523/4885KMT2A 4420/4885
US-20150344499-A1 ARYL SULFIDE DERIVATIVES AND ARYL SULFOXIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES ARSA, SQOR, AHR ALDH1A1 100/4885MEN1 4849/4885KMT2A 2248/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.