Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7414190 | 0.87 | KDM4E (0.39) | MAPTKDM4ETDP1BLMKMT2A | |
| SCHEMBL7412702 | 0.79 | KDM4E (0.44) | MAPTKDM4ETDP1BLMKMT2A | |
| SCHEMBL7439631 | 0.77 | MAPT (0.40) | MAPTKDM4ETDP1BLMKMT2A | |
| SCHEMBL7409625 | 0.74 | KMT2A (0.45) | MAPTKDM4EKMT2AMEN1LMNA | |
| SCHEMBL7411233 | 0.74 | ABCG2 (0.48) | MAPTTDP1KMT2AMEN1ALDH1A1 | |
| SCHEMBL7441183 | 0.74 | LMNA (0.39) | MAPTKDM4ETDP1BLMKMT2A | |
| SCHEMBL7440312 | 0.73 | NCEH1 (0.40) | KDM4EKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL7437559 | 0.73 | KMT2A (0.41) | MAPTKDM4ETDP1BLMKMT2A | |
| SCHEMBL7413138 | 0.72 | ALDH1A1 (0.41) | MAPTKDM4EKMT2AMEN1LMNA | |
| SCHEMBL7410681 | 0.72 | KEAP1 (0.41) | MAPTKDM4ETDP1BLMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4843077-A | Isoquinoline derivatives having renal vasodilating properties and/or cardiotonic properties and/or phosphodiesterase inhibiting properties | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-06-27 | — | — | US | claimed |
| US-4843077-A | Isoquinoline derivatives having renal vasodilating properties and/or cardiotonic properties and/or phosphodiesterase inhibiting properties | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-06-27 | — | — | US | disclosed |