Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CES2 | O00748 | 1/20 | 0.51 |
| ▸ | CES1 | P23141 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MMP13 | P45452 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23014560 | 0.83 | MTNR1A (0.56) | MTNR1BNPC1SMN1; SMN2RAB9ACES2 | |
| SCHEMBL20524444 | 0.82 | KMT2A (0.60) | NPC1ALDH1A1MAPTMAPK1HTT | |
| SCHEMBL7440403 | 0.82 | MTNR1A (0.63) | MTNR1BNPC1SMN1; SMN2RAB9ACES2 | |
| SCHEMBL21509796 | 0.82 | CES2 (0.50) | MTNR1BNPC1SMN1; SMN2RAB9ACES2 | |
| SCHEMBL382162 | 0.81 | ALDH1A1 (0.56) | NPC1SMN1; SMN2RAB9AALDH1A1MAPT | |
| SCHEMBL10782158 | 0.81 | KMT2A (0.54) | NPC1SMN1; SMN2RAB9AALDH1A1MAPT | |
| SCHEMBL3846489 | 0.79 | CES2 (0.61) | MTNR1BNPC1SMN1; SMN2RAB9ACES2 | |
| Methane SCHEMBL11375164 | 0.79 | KMT2A (0.53) | NPC1SMN1; SMN2RAB9AALDH1A1MAPT | |
| SCHEMBL7028931 | 0.79 | KMT2A (0.56) | NPC1SMN1; SMN2RAB9AALDH1A1MAPT | |
| SCHEMBL7413883 | 0.79 | MAPT (0.55) | SMN1; SMN2ALDH1A1MAPTMAPK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0107398-B1 | ORTHO SUBSTITUTED DIHYDROXY-2(1H)QUINAZOLINONE-1-ALKANOIC ACIDS | ORTHO PHARMA CORP (US) | 1988-06-08 | — | — | EP | disclosed |
| US-4631283-A | RENAL VASODILATORS, CARDIOVASCULAR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1986-12-23 | — | — | US | disclosed |
| US-4490374-A | CARDIOVASCULAR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1984-12-25 | — | — | US | disclosed |
| EP-0107398-A1 | Ortho substituted dihydroxy-2(1H)quinazolinone-1-alkanoic acids | ORTHO PHARMACEUTICAL CORPORATION (US) | 1984-05-02 | — | — | EP | disclosed |