Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.55 |
| ▸ | WNT3A | P56704 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31314527 | 0.81 | MEN1 (0.70) | MAPTTSHRCTNNB1WNT3AMAPK1 | |
| SCHEMBL2848397 | 0.81 | MEN1 (0.70) | MAPTTSHRCTNNB1WNT3AMAPK1 | |
| SCHEMBL20524444 | 0.81 | KMT2A (0.60) | MAPTMAPK1KMT2AMEN1CYP2C19 | |
| SCHEMBL7438183 | 0.80 | CTNNB1 (0.55) | MAPTTSHRCTNNB1WNT3AKMT2A | |
| SCHEMBL7410028 | 0.79 | MTNR1B (0.52) | MAPTMAPK1KMT2AALDH1A1POLB | |
| SCHEMBL3652524 | 0.79 | MAPT (0.59) | MAPTTSHRCTNNB1WNT3AMAPK1 | |
| SCHEMBL10459828 | 0.78 | CA12 (0.46) | TSHRKMT2ACYP2C19POLBKDM4E | |
| SCHEMBL10777334 | 0.78 | TSHR (0.61) | MAPTTSHRMAPK1KMT2AALDH1A1 | |
| SCHEMBL7439618 | 0.78 | MAPT (0.52) | MAPTTSHRCTNNB1WNT3AKMT2A | |
| SCHEMBL1110132 | 0.78 | ALDH1A1 (0.58) | MAPTTSHRCTNNB1WNT3AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0107398-B1 | ORTHO SUBSTITUTED DIHYDROXY-2(1H)QUINAZOLINONE-1-ALKANOIC ACIDS | ORTHO PHARMA CORP (US) | 1988-06-08 | — | — | EP | disclosed |
| US-4631283-A | RENAL VASODILATORS, CARDIOVASCULAR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1986-12-23 | — | — | US | disclosed |
| US-4490374-A | CARDIOVASCULAR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1984-12-25 | — | — | US | disclosed |
| EP-0107398-A1 | Ortho substituted dihydroxy-2(1H)quinazolinone-1-alkanoic acids | ORTHO PHARMACEUTICAL CORPORATION (US) | 1984-05-02 | — | — | EP | disclosed |