Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.40 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7414405 | 0.86 | KCNH2 (0.39) | KMT2AGAAMAPKAPK2TDP1SMN1; SMN2 | |
| SCHEMBL7406913 | 0.78 | KDM4E (0.43) | KMT2AGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL7415419 | 0.74 | KDM4E (0.41) | LMNAGAAMAPKAPK2ALDH1A1 | |
| SCHEMBL998068 | 0.63 | ALDH1A1 (0.60) | KMT2ALMNAGAAMAPTNPSR1 | |
| SCHEMBL9734334 | 0.63 | NPC1 (0.42) | CA12CA1CA2CA4CA6 | |
| SCHEMBL16208261 | 0.62 | DDB1 (0.52) | DDB1CRBNKMT2ALMNAGAA | |
| SCHEMBL5843116 | 0.61 | CA12 (0.72) | ROCK2ROCK1CA12CA1CA2 | |
| Carbazole SCHEMBL28283104 | 0.60 | KMT2A (0.73) | ADORA3KMT2ALMNAGAAMAPT | |
| SCHEMBL6203393 | 0.60 | DDB1 (0.64) | DDB1CRBNKMT2AGAAMAPT | |
| SCHEMBL10742560 | 0.59 | CYP1A2 (0.68) | DDB1CRBNKMT2ALMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934319-B1 | 1H-PYRIDO[3,4-b]INDOLE-4-CARBOXAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF IN THERAPEUTICS | SANOFI SYNTHELABO (FR) | 2002-06-05 | — | — | EP | disclosed |
| US-6075021-A | 1H-pyrido[3,4-b]indole-4-carboxamide derivatives, preparation and application thereof in therapeutics | SYNTHELABO (FR) | 2000-06-13 | — | — | US | disclosed |