Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 4/20 | 0.46 |
| ▸ | CTSS | P25774 | 3/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 5/20 | 0.45 |
| ▸ | CTSK | P43235 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9383948 | 0.80 | CTSS (0.56) | CTSLCTSSATMTRPM8CTSK | |
| SCHEMBL19519898 | 0.79 | CTSL (0.59) | CTSLCTSSATMTRPM8CTSK | |
| SCHEMBL7328813 | 0.79 | SIRT2 (0.53) | CTSLCTSS | |
| SCHEMBL7328818 | 0.79 | SIRT2 (0.53) | CTSLCTSS | |
| SCHEMBL2722874 | 0.79 | ATM (0.56) | CTSLCTSSATMTRPM8CTSK | |
| SCHEMBL6312509 | 0.79 | ATM (0.56) | CTSLCTSSATMTRPM8CTSK | |
| SCHEMBL6312134 | 0.79 | ATM (0.56) | CTSLCTSSATMTRPM8CTSK | |
| SCHEMBL8668181 | 0.78 | SMN1; SMN2 (0.48) | CTSLCTSSLMNASMN1; SMN2MEN1 | |
| SCHEMBL26047826 | 0.78 | TRPM8 (0.57) | CTSLCTSSATMCYP3A4LMNA | |
| SCHEMBL10188430 | 0.77 | CTRB1 (0.51) | CTSLCTSSATMCYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5776971-A | Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 1998-07-07 | — | — | US | disclosed |
| US-5756533-A | ENZYME INHIBITORS FOR TREATMENT OF AIDS | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |
| US-5705500-A | HIV TREATMENT | G.D. SEARLE & CO. (US) | 1998-01-06 | — | — | US | disclosed |