SCHEMBL7670153

SCHEMBL7670153

CC(C)(C)OC(=O)[C@H](Oc1cncc(-c2cccc(N)c2)c1)N1CCC1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB1 P11230 4/20 0.47
CHRNB2 P17787 4/20 0.47
CHRNB4 P30926 4/20 0.47
CHRNA3 P32297 4/20 0.47
CHRNB3 Q05901 4/20 0.47
ALOX5AP P20292 1/20 0.35
MKNK1 Q9BUB5 2/20 0.34
MKNK2 Q9HBH9 2/20 0.34
MEN1 O00255 1/20 0.34
PSIP1 O75475 1/20 0.34
AXL P30530 1/20 0.34
CYP11B1 P15538 3/20 0.33
CYP11B2 P19099 3/20 0.33
PRMT5 O14744 3/20 0.33
WDR77 Q9BQA1 3/20 0.33
TYRO3 Q06418 1/20 0.33
ITGB3 P05106 1/20 0.33
ITGA2B P08514 1/20 0.33
CHRM3 P20309 1/20 0.33
BACE1 P56817 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7410349 0.79 CHRNB1 (0.38) CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3
SCHEMBL7407935 0.78 ABHD6 (0.35) CYP11B1CYP11B2
SCHEMBL6583035 0.78 CHRNB2 (0.39) CHRNB2
SCHEMBL7407010 0.78 CHRNB2 (0.39) CHRNB2
SCHEMBL7411612 0.76 CHRNB2 (0.41) CHRNB2CHRNB4CHRNA3CYP11B2
SCHEMBL8507386 0.76 CHRNB2 (0.39) CHRNB2
SCHEMBL8507388 0.76 CHRNB2 (0.39) CHRNB2
SCHEMBL7416527 0.75 PTGS2 (0.33)
SCHEMBL6589354 0.73 CHRNB1 (0.67) CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3
SCHEMBL6584564 0.73 CHRNB1 (0.67) CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6437138-B1 5-BROMO-6-CHLORO-3-(2-(S)-AZETIDINYL OR PYRROLIDINYL-METHOXY) PYRIDINE INTERMEDIATES FOR THE 5-SUBSTITUTED COMPOUNDS WHICH ARE POTENT LIGANDS AT NEURONAL NICOTINIC CHOLINERGIC CHANNEL RECEPTORS, NEUROTRANSMITTER CONTROLLING AGENTS ABBOTT LABORATORIES 2002-08-20 US disclosed