Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 17/20 | 0.69 |
| ▸ | ITGA2B | P08514 | 17/20 | 0.69 |
| ▸ | PPARG | P37231 | 2/20 | 0.52 |
| ▸ | ITGAV | P06756 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7415198 | 0.95 | ITGB3 (0.63) | ITGB3ITGA2BPPARGITGAVCHRM2 | |
| SCHEMBL7420817 | 0.88 | ITGB3 (0.56) | ITGB3ITGA2BITGAVCHRM2SLC6A4 | |
| SCHEMBL7414099 | 0.88 | ITGB3 (0.53) | ITGB3ITGA2BPPARGITGAVCHRM2 | |
| SCHEMBL7409585 | 0.87 | ITGB3 (0.61) | ITGB3ITGA2BITGAV | |
| SCHEMBL7415221 | 0.87 | ITGB3 (0.53) | ITGB3ITGA2B | |
| SCHEMBL7411712 | 0.87 | TDP1 (0.59) | ITGB3ITGA2B | |
| SCHEMBL7420563 | 0.87 | MMP2 (0.61) | ITGB3ITGA2B | |
| SCHEMBL7415975 | 0.85 | ITGB3 (0.59) | ITGB3ITGA2BITGAVCHRM2SLC6A4 | |
| SCHEMBL7412781 | 0.85 | L3MBTL1 (0.53) | ITGB3ITGA2BPPARGITGAV | |
| SCHEMBL7409546 | 0.85 | ITGB3 (0.51) | ITGB3ITGA2BPPARGITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6344484-B1 | TREATMENT OF TUMOR GROWTH, METASTASIS, OSTEOPOROSIS, RESTENOSIS, INFLAMMATION, MACULAR DEGENERATION, DIABETIC RETINOPATHY, AND RHEUMATOID ARTHRITIS | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2002-02-05 | — | — | US | claimed |
| EP-1159262-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2001-12-05 | — | — | EP | claimed |
| WO-2000047552-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2000-08-17 | — | — | WO | claimed |