Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 18/20 | 0.59 |
| ▸ | ITGA2B | P08514 | 18/20 | 0.59 |
| ▸ | ITGAV | P06756 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.41 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7417991 | 0.95 | ITGB3 (0.55) | ITGB3ITGA2BITGAVCHRM2SLC6A4 | |
| Trifluoroacetic Acid SCHEMBL7409565 | 0.87 | ITGB3 (0.66) | ITGB3ITGA2BITGAVCHRM2SLC6A4 | |
| SCHEMBL7412450 | 0.85 | ITGB3 (0.69) | ITGB3ITGA2BITGAVCHRM2SLC6A4 | |
| SCHEMBL7417997 | 0.85 | ITGB3 (0.44) | ITGB3ITGA2BITGAVCHRM2SLC6A4 | |
| SCHEMBL7409585 | 0.84 | ITGB3 (0.61) | ITGB3ITGA2BITGAV | |
| SCHEMBL7417646 | 0.83 | MMP2 (0.56) | ITGB3ITGA2B | |
| SCHEMBL7418686 | 0.82 | ITGB1 (0.51) | ITGB3ITGA2BITGAVITGB1ITGA5 | |
| SCHEMBL7694797 | 0.82 | ITGB3 (0.49) | ITGB3ITGA2BITGAVITGB1ITGA5 | |
| SCHEMBL7420817 | 0.82 | ITGB3 (0.56) | ITGB3ITGA2BITGAVCHRM2SLC6A4 | |
| SCHEMBL7414099 | 0.82 | ITGB3 (0.53) | ITGB3ITGA2BITGAVCHRM2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6344484-B1 | TREATMENT OF TUMOR GROWTH, METASTASIS, OSTEOPOROSIS, RESTENOSIS, INFLAMMATION, MACULAR DEGENERATION, DIABETIC RETINOPATHY, AND RHEUMATOID ARTHRITIS | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2002-02-05 | — | — | US | claimed |
| EP-1159262-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2001-12-05 | — | — | EP | claimed |
| WO-2000047552-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2000-08-17 | — | — | WO | claimed |