Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 10/20 | 0.60 |
| ▸ | CTSD | P07339 | 1/20 | 0.60 |
| ▸ | CTSE | P14091 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7410615 | 0.90 | KMT2A (0.51) | RENCTSDCTSESMN1; SMN2CYP1A2 | |
| SCHEMBL7417716 | 0.82 | BACE1 (0.52) | RENCTSDCTSEMAPTMAPK1 | |
| SCHEMBL7362226 | 0.82 | ALDH1A1 (0.62) | RENCTSDCTSESMN1; SMN2CYP1A2 | |
| SCHEMBL9497300 | 0.81 | CYP3A4 (0.50) | RENSMN1; SMN2CYP1A2ALDH1A1CYP3A4 | |
| SCHEMBL7954670 | 0.81 | SMN1; SMN2 (0.50) | RENCTSDCTSESMN1; SMN2CYP1A2 | |
| SCHEMBL7366909 | 0.78 | SMN1; SMN2 (0.49) | RENCTSDCTSESMN1; SMN2CYP1A2 | |
| SCHEMBL7361383 | 0.77 | REN (0.63) | RENCTSDCTSE | |
| SCHEMBL29611056 | 0.76 | SMN1; SMN2 (0.61) | SMN1; SMN2MAPTALDH1A1POLBNPC1 | |
| SCHEMBL4678395 | 0.76 | SMN1; SMN2 (0.61) | SMN1; SMN2MAPTALDH1A1POLBNPC1 | |
| SCHEMBL7412829 | 0.76 | CYP2D6 (0.42) | RENCTSDCTSECYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5389647-A | A prodrugs as hypotensive agents, treating congestive heart failure, urogenital disorders, vision defects | ABBOTT LABORATORIES (US) | 1995-02-14 | — | — | US | disclosed |
| US-5244910-A | Treating hypertension, congestive heart failure | ABBOTT LABORATORIES (US) | 1993-09-14 | — | — | US | disclosed |
| WO-1992003429-A1 | RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1992-03-05 | — | — | WO | disclosed |