Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 9/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | FASN | P49327 | 3/20 | 0.34 |
| ▸ | F2 | P00734 | 2/20 | 0.34 |
| ▸ | F10 | P00742 | 2/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.34 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.34 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7420019 | 0.84 | FASN (0.34) | FASNKDM1A | |
| SCHEMBL7413736 | 0.74 | KDM1A (0.38) | HSD11B1F2F10PRSS1PRSS2 | |
| SCHEMBL7412573 | 0.73 | ALDH1A1 (0.42) | HSD11B1FASNF2F10PRSS1 | |
| SCHEMBL7414205 | 0.72 | F2 (0.31) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL7410812 | 0.71 | HSD11B1 (0.52) | HSD11B1F2F10PRSS1PRSS2 | |
| SCHEMBL5091269 | 0.66 | HSD11B1 (0.61) | HSD11B1ALDH1A1CYP3A4CYP2C19MEN1 | |
| SCHEMBL7412123 | 0.65 | HSD11B1 (0.48) | HSD11B1ALDH1A1MAPK1CYP2C19MEN1 | |
| SCHEMBL8032174 | 0.65 | F2 (0.58) | HSD11B1F2F10PRSS1PRSS2 | |
| SCHEMBL5089199 | 0.64 | FASN (0.41) | HSD11B1FASN | |
| SCHEMBL7415072 | 0.64 | F2 (0.48) | HSD11B1F2F10PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248770-B1 | CARDIOVASCULAR DISORDERS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-06-19 | — | — | US | disclosed |
| EP-1095025-A2 | BENZIMIDAZOLES, PRODUCTION THEREOF AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM KG (DE) | 2001-05-02 | — | — | EP | disclosed |
| WO-2000001704-A2 | BENZIMIDAZOLES, PRODUCTION THEREOF AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-01-13 | — | — | WO | disclosed |