Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 7/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 9/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.34 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7409726 | 0.79 | CYP11B2 (0.36) | KDM1APIN1 | |
| SCHEMBL7413734 | 0.74 | HSD11B1 (0.36) | KDM1AHSD11B1F2F10PRSS1 | |
| SCHEMBL5091269 | 0.67 | HSD11B1 (0.61) | HSD11B1 | |
| SCHEMBL7412573 | 0.67 | ALDH1A1 (0.42) | HSD11B1F2F10PRSS1PRSS2 | |
| SCHEMBL5089199 | 0.64 | FASN (0.41) | HSD11B1 | |
| SCHEMBL7415075 | 0.64 | F2 (0.74) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL8032174 | 0.64 | F2 (0.58) | HSD11B1F2F10PRSS1PRSS2 | |
| SCHEMBL5099562 | 0.63 | NPC1 (0.43) | — | |
| SCHEMBL7415072 | 0.62 | F2 (0.48) | HSD11B1F2F10PRSS1PRSS2 | |
| SCHEMBL5099064 | 0.61 | MCHR1 (0.42) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248770-B1 | CARDIOVASCULAR DISORDERS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-06-19 | — | — | US | disclosed |
| EP-1095025-A2 | BENZIMIDAZOLES, PRODUCTION THEREOF AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM KG (DE) | 2001-05-02 | — | — | EP | disclosed |
| WO-2000001704-A2 | BENZIMIDAZOLES, PRODUCTION THEREOF AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-01-13 | — | — | WO | disclosed |