Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 8/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 7/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 4/20 | 0.37 |
| ▸ | TMPRSS6 | Q8IU80 | 4/20 | 0.37 |
| ▸ | ITGAV | P06756 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7414101 | 0.91 | ITGB3 (0.40) | ITGB3ITGA2BPOLBF2TMPRSS6 | |
| SCHEMBL7410416 | 0.90 | L3MBTL1 (0.41) | ITGB3ITGA2BF2TMPRSS6ITGAV | |
| SCHEMBL7414402 | 0.90 | POLB (0.49) | ITGB3ITGA2BPOLBF2TMPRSS6 | |
| SCHEMBL7415119 | 0.90 | ITGB1 (0.39) | ITGB3ITGA2BPOLBF2TMPRSS6 | |
| SCHEMBL7413080 | 0.90 | MMP7 (0.40) | ITGB3ITGA2BPOLBF2TMPRSS6 | |
| SCHEMBL7418586 | 0.90 | CYP3A4 (0.41) | ITGB3ITGA2BF2TMPRSS6ITGAV | |
| SCHEMBL7694227 | 0.89 | F10 (0.41) | ITGB3ITGA2BF2TMPRSS6 | |
| Trifluoroacetic Acid SCHEMBL7415440 | 0.89 | ITGB3 (0.49) | ITGB3ITGA2BPOLBF2TMPRSS6 | |
| SCHEMBL7414443 | 0.89 | ITGB1 (0.39) | ITGB3ITGA2BPOLBF2TMPRSS6 | |
| SCHEMBL7412871 | 0.89 | MEN1 (0.40) | ITGB3ITGA2BPOLBF2TMPRSS6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6344484-B1 | TREATMENT OF TUMOR GROWTH, METASTASIS, OSTEOPOROSIS, RESTENOSIS, INFLAMMATION, MACULAR DEGENERATION, DIABETIC RETINOPATHY, AND RHEUMATOID ARTHRITIS | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2002-02-05 | — | — | US | disclosed |
| EP-1159262-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000047552-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2000-08-17 | — | — | WO | disclosed |