Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 7/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 7/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | ALPL | P05186 | 2/20 | 0.34 |
| ▸ | HSD17B1 | P14061 | 5/20 | 0.34 |
| ▸ | HSD17B2 | P37059 | 5/20 | 0.34 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7416198 | 0.90 | ITGB3 (0.43) | MEN1KMT2AITGB3ITGA2BPPARG | |
| SCHEMBL7471115 | 0.90 | ITGB3 (0.44) | MEN1KMT2AITGB3ITGA2BADAMTS4 | |
| SCHEMBL7412871 | 0.89 | MEN1 (0.40) | MEN1KMT2AITGB3ITGA2BPOLB | |
| SCHEMBL7417980 | 0.89 | MEN1 (0.40) | MEN1KMT2AITGB3ITGA2BPTPN1 | |
| SCHEMBL7414783 | 0.88 | CYP3A4 (0.43) | MEN1KMT2AITGB3ITGA2BALPL | |
| SCHEMBL7412629 | 0.86 | CTSL (0.43) | ITGB3ITGA2B | |
| SCHEMBL7419584 | 0.85 | F2 (0.42) | MEN1KMT2AITGB3ITGA2BPTPN1 | |
| SCHEMBL7414402 | 0.84 | POLB (0.49) | MEN1KMT2AITGB3ITGA2BPOLB | |
| SCHEMBL7410463 | 0.84 | ITGB3 (0.38) | MEN1KMT2AITGB3ITGA2BPOLB | |
| SCHEMBL7415207 | 0.83 | ITGB3 (0.50) | ITGB3ITGA2BPPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6344484-B1 | TREATMENT OF TUMOR GROWTH, METASTASIS, OSTEOPOROSIS, RESTENOSIS, INFLAMMATION, MACULAR DEGENERATION, DIABETIC RETINOPATHY, AND RHEUMATOID ARTHRITIS | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2002-02-05 | — | — | US | disclosed |
| EP-1159262-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000047552-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2000-08-17 | — | — | WO | disclosed |