Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 13/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 13/20 | 0.50 |
| ▸ | PPARG | P37231 | 3/20 | 0.39 |
| ▸ | F2 | P00734 | 2/20 | 0.35 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.35 |
| ▸ | ITGAV | P06756 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7415235 | 0.89 | KCNA5 (0.44) | ITGB3ITGA2BF2TMPRSS6ITGAV | |
| SCHEMBL7417563 | 0.89 | ITGB3 (0.39) | ITGB3ITGA2BF2TMPRSS6ITGAV | |
| SCHEMBL7415446 | 0.89 | ITGB3 (0.39) | ITGB3ITGA2BPPARGF2TMPRSS6 | |
| SCHEMBL7409569 | 0.89 | ITGB3 (0.54) | ITGB3ITGA2BITGAVCHRM2SLC6A4 | |
| SCHEMBL7416574 | 0.89 | ITGB3 (0.45) | ITGB3ITGA2BF2TMPRSS6ITGAV | |
| SCHEMBL7694791 | 0.89 | MMP2 (0.45) | ITGB3ITGA2BF2TMPRSS6ITGAV | |
| SCHEMBL7417592 | 0.88 | ITGB3 (0.49) | ITGB3ITGA2BF2TMPRSS6ITGAV | |
| SCHEMBL7414101 | 0.88 | ITGB3 (0.40) | ITGB3ITGA2BF2TMPRSS6 | |
| Trifluoroacetic Acid SCHEMBL7415198 | 0.88 | ITGB3 (0.63) | ITGB3ITGA2BPPARGITGAVCHRM2 | |
| SCHEMBL7417997 | 0.88 | ITGB3 (0.44) | ITGB3ITGA2BF2TMPRSS6ITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1159262-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000047552-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2000-08-17 | — | — | WO | disclosed |