Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.57 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.57 |
| ▸ | LTA4H | P09960 | 1/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | NQO1 | P15559 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA6 | P23280 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14686116 | 0.96 | LTA4H (0.59) | ESR1ESR2LTA4HAKR1C3AKR1C2 | |
| SCHEMBL29779700 | 0.88 | NQO1 (0.62) | ESR2AKR1C3AKR1C2CYP1A2NQO1 | |
| SCHEMBL3821099 | 0.88 | NQO1 (0.62) | ESR2AKR1C3AKR1C2CYP1A2NQO1 | |
| SCHEMBL6048619 | 0.85 | MEN1 (0.58) | ESR1ESR2LTA4HCYP1A2KMT2A | |
| SCHEMBL3764671 | 0.84 | NQO1 (0.52) | ESR1ESR2LTA4HAKR1C3AKR1C2 | |
| SCHEMBL23458226 | 0.83 | NQO1 (0.62) | ESR2LTA4HAKR1C3AKR1C2CYP1A2 | |
| SCHEMBL29629327 | 0.83 | NQO1 (0.68) | ESR2LTA4HAKR1C3AKR1C2CYP1A2 | |
| SCHEMBL3825385 | 0.83 | NQO1 (0.68) | ESR2LTA4HAKR1C3AKR1C2CYP1A2 | |
| SCHEMBL2735970 | 0.81 | KMT2A (0.48) | ESR1ESR2CYP1A2KMT2AMEN1 | |
| SCHEMBL6048615 | 0.81 | NR5A1 (0.67) | LTA4HKMT2AMEN1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430006-B1 | CYCLOPENTA[C]PYRROLE-2-CARBOXYLATE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2014-11-26 | — | — | EP | disclosed |
| US-8697883-B2 | Cyclopenta[C]pyrrole-2-carboxylate derivatives, preparation thereof and therapeutic use thereof | SANOFI (FR) | 2014-04-15 | — | — | US | disclosed |
| US-20120095040-A1 | CYCLOPENTA[C]PYRROLE-2-CARBOXYLATE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-04-19 | — | — | US | disclosed |
| EP-2430006-A1 | CYCLOPENTA[C]PYRROLE-2-CARBOXYLATE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010130944-A1 | CYCLOPENTA[C]PYRROLE-2-CARBOXYLATE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-11-18 | — | — | WO | disclosed |
| US-7151070-B2 | Chiral catalyst, process for preparing the same and its use in the oxidate coupling of naphthols | CHENGDU INSTITUTE OF ORGANIC CHEMISTRY CHINESE ACADEMY OF SCIENCES (CN) | 2006-12-19 | — | — | US | disclosed |
| US-20050256345-A1 | Chiral catalyst, process for preparing the same and its use in the oxidate coupling of naphthols | CHENGDU INSTITUTE OF ORGANIC CHEMISTRY CHINESE ACADEMY OF SCIENCES (CN) | 2005-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050256345-A1 | Chiral catalyst, process for preparing the same and its use in the oxidate coupling of naphthols | BCAT2, BCAT1, NDUFV2 | ESR1 2002/4885ESR2 1763/4885LTA4H 1460/4885 |
| US-20120095040-A1 | CYCLOPENTA[C]PYRROLE-2-CARBOXYLATE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | EPOR, ACAD9, CBR1 | ESR1 2159/4885ESR2 1739/4885LTA4H 3557/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.