Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 5/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.38 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.38 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7414115 | 0.92 | KMT2A (0.44) | CTSDTLR8TLR7MEN1KMT2A | |
| SCHEMBL7402968 | 0.89 | HSP90AA1 (0.40) | CTSDNPC1KMT2AALDH1A1L3MBTL3 | |
| SCHEMBL7592584 | 0.83 | KMT2A (0.44) | MEN1KMT2APOLBHPGDADORA2A | |
| SCHEMBL7380703 | 0.83 | NOS3 (0.37) | NPC1MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL7375377 | 0.75 | NOS2 (0.42) | NPC1MEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL7423018 | 0.72 | NOS3 (0.40) | NPC1POLBALDH1A1 | |
| SCHEMBL7423582 | 0.72 | NOS2 (0.41) | — | |
| SCHEMBL7417662 | 0.69 | NOS2 (0.41) | — | |
| SCHEMBL7396252 | 0.69 | ALDH1A1 (0.37) | ALDH1A1 | |
| SCHEMBL7386220 | 0.69 | AOC3 (0.37) | TLR7MEN1KMT2AHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000073313-A1 | NEW TRICYCLIC AMIDINE DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRAZENECA AB (SE) | 2000-12-07 | — | — | WO | disclosed |