Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 5/20 | 0.43 |
| ▸ | SORT1 | Q99523 | 5/20 | 0.43 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.40 |
| ▸ | ACE | P12821 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SHMT1 | P34896 | 2/20 | 0.34 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7423334 | 0.88 | DHFR (0.34) | GRNSORT1ALDH1A1MAPK1DHFR | |
| SCHEMBL7426448 | 0.84 | GRN (0.44) | GRNSORT1ACE2ACEALDH1A1 | |
| SCHEMBL7424365 | 0.83 | GRN (0.43) | GRNSORT1ACE2ACEALDH1A1 | |
| SCHEMBL7425815 | 0.79 | GRN (0.43) | GRNSORT1ACE2ACEALDH1A1 | |
| SCHEMBL7419023 | 0.77 | GRN (0.47) | GRNSORT1ACE2ACEALDH1A1 | |
| SCHEMBL7422285 | 0.77 | CTSK (0.47) | GRNSORT1ACE2ACEALDH1A1 | |
| SCHEMBL8254029 | 0.77 | ACE2 (0.53) | GRNSORT1ACE2ACEALDH1A1 | |
| SCHEMBL5870231 | 0.77 | ACE2 (0.53) | GRNSORT1ACE2ACEALDH1A1 | |
| SCHEMBL7421108 | 0.76 | SORT1 (0.42) | GRNSORT1ACE2ACEALDH1A1 | |
| SCHEMBL7420461 | 0.76 | BCHE (0.37) | ALDH1A1MAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |