Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
| ▸ | GRN | P28799 | 3/20 | 0.44 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.44 |
| ▸ | SHMT1 | P34896 | 2/20 | 0.41 |
| ▸ | SHMT2 | P34897 | 2/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.37 |
| ▸ | ACE | P12821 | 3/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | LDHA | P00338 | 1/20 | 0.35 |
| ▸ | LDHB | P07195 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7426736 | 0.88 | CTSK (0.48) | CTSKSORT1SHMT1SHMT2MAPK1 | |
| SCHEMBL1655302 | 0.86 | CTSK (0.62) | CTSKGRNSORT1PDE5ALDHA | |
| SCHEMBL7425252 | 0.84 | CTSK (0.54) | CTSKPDE5ALDHALDHBLMNA | |
| SCHEMBL7424365 | 0.83 | GRN (0.43) | CTSKGRNSORT1SHMT1SHMT2 | |
| SCHEMBL7426448 | 0.82 | GRN (0.44) | GRNSORT1ACE2ACEADRB2 | |
| SCHEMBL7420772 | 0.80 | ALDH1A1 (0.51) | CTSKSHMT1SHMT2TLR7MAPK1 | |
| SCHEMBL7423860 | 0.80 | SORT1 (0.44) | GRNSORT1ACE2ACEADRB2 | |
| SCHEMBL7382345 | 0.79 | CTSK (0.41) | CTSKGRNSORT1MAPK1PDE5A | |
| SCHEMBL7417883 | 0.78 | CTSK (0.55) | CTSKPDE5ALDHALDHBMAPT | |
| SCHEMBL7424643 | 0.78 | CTSK (0.39) | CTSKSHMT1SHMT2ACE2ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |