Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.33 |
| ▸ | PTPRB | P23467 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | GRN | P28799 | 1/20 | 0.32 |
| ▸ | PYGL | P06737 | 1/20 | 0.32 |
| ▸ | MME | P08473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7417825 | 0.88 | GRN (0.43) | DHFRALDH1A1MAPK1SORT1MAPT | |
| SCHEMBL7424812 | 0.84 | SMN1; SMN2 (0.34) | ALDH1A1CYP2C19TAS1R3TAS1R1MEN1 | |
| SCHEMBL7426920 | 0.83 | CTSK (0.38) | DHFRALDH1A1CYP2C19TAS1R3TAS1R1 | |
| SCHEMBL7425447 | 0.79 | DHFR (0.34) | DHFRALDH1A1CYP2C19TAS1R3TAS1R1 | |
| SCHEMBL7420461 | 0.76 | BCHE (0.37) | ALDH1A1MEN1KMT2AMMP2MAPK1 | |
| SCHEMBL7426736 | 0.76 | CTSK (0.48) | ALDH1A1CYP2C19TAS1R3TAS1R1MEN1 | |
| SCHEMBL5869842 | 0.76 | ACE2 (0.39) | ALDH1A1CYP2C19TAS1R3TAS1R1MEN1 | |
| SCHEMBL8430007 | 0.76 | ACE2 (0.39) | ALDH1A1CYP2C19TAS1R3TAS1R1MEN1 | |
| SCHEMBL7429293 | 0.76 | SORT1 (0.34) | DHFRALDH1A1CYP2C19TAS1R3TAS1R1 | |
| SCHEMBL7426239 | 0.76 | MEN1 (0.43) | ALDH1A1MEN1KMT2ASORT1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |