Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEP1B | Q16820 | 3/20 | 0.72 |
| ▸ | MMP2 | P08253 | 5/20 | 0.70 |
| ▸ | MMP9 | P14780 | 5/20 | 0.70 |
| ▸ | MMP13 | P45452 | 4/20 | 0.65 |
| ▸ | MMP14 | P50281 | 2/20 | 0.65 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.65 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | MMP1 | P03956 | 3/20 | 0.58 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | MMP8 | P22894 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
| ▸ | MMP3 | P08254 | 1/20 | 0.54 |
| ▸ | MMP7 | P09237 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18498698 | 0.87 | MEN1 (0.57) | MEP1BMMP2MMP9MMP13MMP14 | |
| SCHEMBL7413923 | 0.83 | MMP2 (0.72) | MEP1BMMP2MMP9MMP13MMP14 | |
| SCHEMBL9577239 | 0.82 | SIGMAR1 (0.68) | MMP2MMP9MMP13MEN1KMT2A | |
| SCHEMBL7417568 | 0.81 | MMP13 (0.71) | MEP1BMMP2MMP9MMP13MMP14 | |
| SCHEMBL18498935 | 0.81 | IDO1 (0.56) | MMP2MMP9MMP13MEN1KMT2A | |
| SCHEMBL13401889 | 0.80 | KMT2A (0.67) | MMP2MMP9MEN1KMT2ARAB9A | |
| SCHEMBL19334435 | 0.79 | RAB9A (0.73) | MMP2MMP9MMP13MEN1KMT2A | |
| SCHEMBL1348420 | 0.79 | ALDH1A1 (0.64) | MMP2MMP9MMP13MEN1KMT2A | |
| SCHEMBL18498803 | 0.79 | ALDH1A1 (0.58) | MMP2MMP9MMP13MEN1KMT2A | |
| SCHEMBL13401888 | 0.78 | POLB (0.70) | MEN1KMT2ARAB9AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218389-B1 | FOR THERAPY AND PROPHYLAXIS OF ARTHRITIS, CANCER, CARDIOVASCULAR DISORDERS; SKIN DISORDERS; OCULAR DISORDERS; INFLAMMATION AND GUM DISEASES, MULTIPLE SCLEROSIS, CACHEXIA, PREVENTING LOOSENING OF PROSTHETIC DEVICES | THE PROCTER & GAMBLE CO. | 2001-04-17 | — | — | US | disclosed |
| EP-1009737-A2 | SULFONYLAMINO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2000-06-21 | — | — | EP | disclosed |
| WO-1999006340-A2 | SULFONYLAMINO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |