Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS2 | O15393 | 2/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 10/20 | 0.46 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.42 |
| ▸ | F2 | P00734 | 3/20 | 0.42 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.42 |
| ▸ | PLG | P00747 | 2/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.42 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.42 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.42 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | S100B | P04271 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | AOC1 | P19801 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1283675 | 0.78 | PRSS1 (0.42) | TMPRSS2PRSS1PRMT1F2ST14 | |
| SCHEMBL10718792 | 0.72 | — | — | |
| SCHEMBL6993806 | 0.72 | L3MBTL1 (0.43) | TMPRSS2PRSS1PRMT1F2ST14 | |
| SCHEMBL3873648 | 0.71 | PRSS1 (0.51) | TMPRSS2PRSS1PRMT1F2ST14 | |
| SCHEMBL10785918 | 0.71 | KCNA3 (0.43) | PRSS1DRD3 | |
| SCHEMBL5583706 | 0.70 | KCNA3 (0.65) | PRSS1F2PLGDRD3PRSS2 | |
| SCHEMBL249623 | 0.70 | ALDH1A1 (0.46) | TMPRSS2PRSS1PRMT1F2ST14 | |
| SCHEMBL2182069 | 0.70 | TAAR1 (0.46) | — | |
| SCHEMBL921280 | 0.69 | KCNA3 (0.44) | TMPRSS2PRSS1PRMT1F2ST14 | |
| SCHEMBL7559437 | 0.69 | HDAC1 (0.46) | TMPRSS2PRSS1PRMT1F2ST14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020061885-A1 | Tetrahydroisoquinoline-3-carboxylic acid alkoxyguanidines as integrin antagonists | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2002-05-23 | — | — | US | disclosed |
| US-20020037897-A1 | Tetrahydroisoquinoline-3-carboxylic acid alkoxyguanidines as integrin antagonists | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2002-03-28 | — | — | US | disclosed |
| WO-2002012193-A1 | TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID ALKOXYGUANIDINES AS INTEGRIN ANTAGONISTS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2002-02-14 | — | — | WO | disclosed |
| US-6344484-B1 | TREATMENT OF TUMOR GROWTH, METASTASIS, OSTEOPOROSIS, RESTENOSIS, INFLAMMATION, MACULAR DEGENERATION, DIABETIC RETINOPATHY, AND RHEUMATOID ARTHRITIS | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2002-02-05 | — | — | US | disclosed |
| EP-1159262-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000047552-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2000-08-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020037897-A1 | Tetrahydroisoquinoline-3-carboxylic acid alkoxyguanidines as integrin antagonists | ADGRE5, ITGAL, VCAM1 | TMPRSS2 1823/4885PRSS1 3989/4885PRMT1 887/4885 |
| US-20020061885-A1 | Tetrahydroisoquinoline-3-carboxylic acid alkoxyguanidines as integrin antagonists | ITGAL, ITGAV, ITGB3 | TMPRSS2 3113/4885PRSS1 4336/4885PRMT1 1700/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.