Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 6/20 | 0.65 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.65 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.65 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.65 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.65 |
| ▸ | PLG | P00747 | 1/20 | 0.65 |
| ▸ | ITGB3 | P05106 | 7/20 | 0.59 |
| ▸ | ITGA2B | P08514 | 7/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | NAAA | Q02083 | 1/20 | 0.50 |
| ▸ | F10 | P00742 | 1/20 | 0.49 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4420271 | 0.88 | F2 (0.67) | F2PRSS1TPSAB1TPSD1TPSG1 | |
| SCHEMBL7428430 | 0.79 | TPSAB1 (1.00) | F2PRSS1TPSAB1TPSD1TPSG1 | |
| SCHEMBL7076872 | 0.78 | NAAA (0.55) | F2PRSS1TPSAB1TPSD1TPSG1 | |
| SCHEMBL7072198 | 0.77 | F2 (0.53) | F2PRSS1TPSAB1TPSD1TPSG1 | |
| SCHEMBL7075075 | 0.77 | CNR1 (0.56) | F2PRSS1TPSAB1TPSD1TPSG1 | |
| SCHEMBL7076655 | 0.77 | ALDH1A1 (0.55) | F2PRSS1TPSAB1TPSD1TPSG1 | |
| SCHEMBL7118598 | 0.76 | ITGB3 (0.74) | F2PRSS1PLGITGB3ITGA2B | |
| SCHEMBL7074868 | 0.76 | KMT2A (0.52) | F2PRSS1TPSAB1TPSD1TPSG1 | |
| SCHEMBL27618024 | 0.74 | F2 (0.63) | F2PRSS1TPSAB1TPSD1TPSG1 | |
| SCHEMBL7131839 | 0.74 | NPC1 (0.86) | NPC1TDP1NAAAFKBP1ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211228-B1 | COMPOUNDS WITH AMINO, GUANIDINO AND AMIDINO HETEROCYCLIC COMPOUNDS | AXYS PHARMACEUTICALS, INC | 2001-04-03 | — | — | US | disclosed |
| EP-0782571-A1 | COMPOSITIONS AND METHODS FOR TREATING MAST-CELL INFLAMMATORY CONDITION | ARRIS PHARMACEUTICAL CORPORATION (US) | 1997-07-09 | — | — | EP | disclosed |
| WO-1996009297-A1 | COMPOSITIONS AND METHODS FOR TREATING MAST-CELL INFLAMMATORY CONDITION | ARRIS PHARMACEUTICAL CORPORATION (US) | 1996-03-28 | — | — | WO | disclosed |