Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL742036 | 0.74 | KMT2A (0.44) | KMT2ANFKB1GRIN2B | |
| SCHEMBL4980874 | 0.70 | KMT2A (0.52) | KMT2AJAK2JAK1OPRM1ALOX15 | |
| SCHEMBL1859933 | 0.66 | KDM4E (0.36) | KDM4EMEN1KMT2ALMNACYP3A4 | |
| SCHEMBL740445 | 0.66 | KDM4E (0.36) | KDM4EMEN1KMT2ALMNACYP3A4 | |
| SCHEMBL740446 | 0.66 | KDM4E (0.36) | KDM4EMEN1KMT2ALMNACYP3A4 | |
| SCHEMBL29214271 | 0.65 | HSD11B1 (0.41) | MEN1KMT2ACYP3A4GRIN2B | |
| SCHEMBL923461 | 0.65 | MAOA (0.48) | KDM4ELMNA | |
| SCHEMBL7468310 | 0.64 | ACHE (0.49) | OPRM1 | |
| SCHEMBL6640538 | 0.64 | ALDH1A1 (0.36) | KMT2ANPC1RAB9AJAK2JAK1 | |
| SCHEMBL2811577 | 0.64 | LMNA (0.48) | KDM4EMEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2431370-A1 | Monoacylated 1,2-diaminocycloalkanes | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2012-03-21 | — | — | EP | disclosed |
| US-7935824-B2 | Ethylenediamine derivatives | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2011-05-03 | — | — | US | disclosed |