Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | EIF4E | P06730 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1655302 | 0.86 | CTSK (0.62) | CTSKTP53MEN1KMT2AKDM4E | |
| SCHEMBL7425252 | 0.81 | CTSK (0.54) | CTSKMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL7426736 | 0.81 | CTSK (0.48) | ALDH1A1CTSKTP53MEN1KMT2A | |
| SCHEMBL21560199 | 0.80 | SHMT1 (0.58) | ALDH1A1TP53MEN1KMT2AKDM4E | |
| SCHEMBL21560102 | 0.80 | SHMT1 (0.58) | ALDH1A1TP53MEN1KMT2AKDM4E | |
| SCHEMBL7422285 | 0.80 | CTSK (0.47) | ALDH1A1CTSKKDM4ESMN1; SMN2TLR7 | |
| SCHEMBL5869530 | 0.80 | ALDH1A1 (0.52) | ALDH1A1TP53MEN1KMT2AKDM4E | |
| SCHEMBL5870348 | 0.80 | ALDH1A1 (0.52) | ALDH1A1TP53MEN1KMT2AKDM4E | |
| SCHEMBL5870353 | 0.80 | ALDH1A1 (0.52) | ALDH1A1TP53MEN1KMT2AKDM4E | |
| SCHEMBL7417883 | 0.77 | CTSK (0.55) | CTSKTP53MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |