Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 4/20 | 0.58 |
| ▸ | CCR3 | P51677 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7423471 | 1.00 | HTR7 (0.58) | HTR7CCR3ALDH1A1KDM4ETDP1 | |
| SCHEMBL7423981 | 0.99 | HTR7 (0.57) | HTR7CCR3ALDH1A1KDM4ETDP1 | |
| SCHEMBL6604229 | 0.95 | CACNA1G (0.54) | HTR7CCR3ALDH1A1KDM4ETDP1 | |
| SCHEMBL6005349 | 0.89 | KMT2A (0.58) | HTR7ALDH1A1KDM4ETDP1OPRM1 | |
| SCHEMBL5329789 | 0.88 | L3MBTL1 (0.56) | HTR7ALDH1A1KDM4EMAPK1 | |
| SCHEMBL1206086 | 0.85 | SMN1; SMN2 (0.52) | ALDH1A1KDM4E | |
| SCHEMBL10898699 | 0.84 | ADRA1D (0.53) | ALDH1A1TDP1OPRM1SIGMAR1MAPK1 | |
| SCHEMBL27407955 | 0.83 | ACHE (0.56) | HTR7ALDH1A1MAPK1 | |
| Hydrochloric Acid SCHEMBL10899218 | 0.82 | ALDH1A1 (0.55) | ALDH1A1OPRM1SIGMAR1MAPK1 | |
| SCHEMBL3039551 | 0.82 | L3MBTL1 (0.63) | ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0637318-B1 | PEPTIDE DERIVATIVES CORRESPONDING TO THE CARBOXY TERMINAL SEQUENCE OF HIRUDIN | CIBA GEIGY AG (CH) | 1998-04-01 | — | — | EP | disclosed |
| EP-0815103-A1 | TRYPSIN AND THROMBIN INHIBITORS | Novartis AG (CH) | 1998-01-07 | — | — | EP | disclosed |
| US-5686564-A | Peptide derivatives corresponding to the carboxy terminal sequence of hirudin | NOVARTIS CORPORATION (US) | 1997-11-11 | — | — | US | disclosed |
| WO-1996029327-A1 | TRYPSIN AND THROMBIN INHIBITORS | NOVARTIS AG (CH) | 1996-09-26 | — | — | WO | disclosed |
| EP-0637318-A1 | PEPTIDE DERIVATIVES CORRESPONDING TO THE CARBOXY TERMINAL SEQUENCE OF HIRUDIN | Novartis AG (CH) | 1995-02-08 | — | — | EP | disclosed |
| WO-1993022344-A1 | PEPTIDE DERIVATIVES CORRESPONDING TO THE CARBOXY TERMINAL SEQUENCE OF HIRUDIN | CIBA-GEIGY AG (CH) | 1993-11-11 | — | — | WO | disclosed |