Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7428381 | 0.78 | MEN1 (0.53) | RAB9ASMN1; SMN2MAPTNPC1LMNA | |
| SCHEMBL7424422 | 0.78 | MEN1 (0.53) | RAB9ASMN1; SMN2MAPTNPC1LMNA | |
| SCHEMBL7419841 | 0.77 | KDM4E (0.44) | RAB9ASMN1; SMN2MAPTNPC1ALDH1A1 | |
| SCHEMBL7424619 | 0.75 | MRE11 (0.46) | RAB9AMAPTNPC1APPMEN1 | |
| SCHEMBL22491245 | 0.71 | MAPT (0.48) | RAB9ASMN1; SMN2MAPTNPC1LMNA | |
| SCHEMBL7416089 | 0.71 | ALOX5 (0.44) | GAA | |
| SCHEMBL7422761 | 0.69 | RAB9A (0.50) | RAB9ASMN1; SMN2MAPTNPC1LMNA | |
| SCHEMBL7420893 | 0.66 | ALDH1A1 (0.41) | RAB9ASMN1; SMN2MAPTNPC1LMNA | |
| SCHEMBL7421514 | 0.66 | ALDH1A1 (0.44) | RAB9ASMN1; SMN2MAPTNPC1LMNA | |
| SCHEMBL7426239 | 0.66 | MEN1 (0.43) | RAB9ASMN1; SMN2MAPTNPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |