Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | CLK1 | P49759 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | DNM1L | O00429 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 11/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5870572 | 0.82 | PLA2G10 (0.55) | PLA2G10NPC1RAB9ACLK1KDM4E | |
| SCHEMBL5869975 | 0.82 | PLA2G10 (0.55) | PLA2G10NPC1RAB9ACLK1KDM4E | |
| SCHEMBL1655302 | 0.80 | CTSK (0.62) | NPC1RAB9AKDM4ESMN1; SMN2CTSK | |
| SCHEMBL7425252 | 0.79 | CTSK (0.54) | NPC1RAB9AKDM4ESMN1; SMN2CTSK | |
| SCHEMBL7426736 | 0.78 | CTSK (0.48) | KDM4EALDH1A1SMN1; SMN2CTSKTAS1R3 | |
| SCHEMBL7422285 | 0.77 | CTSK (0.47) | KDM4EALDH1A1SMN1; SMN2CTSK | |
| SCHEMBL7420772 | 0.76 | ALDH1A1 (0.51) | KDM4EALDH1A1SMN1; SMN2CTSKKMT2A | |
| SCHEMBL7422924 | 0.73 | PLA2G10 (0.53) | PLA2G10NPC1RAB9ACLK1KDM4E | |
| SCHEMBL7417883 | 0.72 | CTSK (0.55) | NPC1RAB9AKDM4ESMN1; SMN2CTSK | |
| SCHEMBL7382345 | 0.71 | CTSK (0.41) | NPC1RAB9AALDH1A1SMN1; SMN2CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |