Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT1 | P34896 | 12/20 | 0.56 |
| ▸ | SHMT2 | P34897 | 8/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | PRKCG | P05129 | 1/20 | 0.39 |
| ▸ | PRKCB | P05771 | 1/20 | 0.39 |
| ▸ | IL1R1 | P14778 | 1/20 | 0.39 |
| ▸ | PRKCA | P17252 | 1/20 | 0.39 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.39 |
| ▸ | PRKCH | P24723 | 1/20 | 0.39 |
| ▸ | PRKCI | P41743 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7422281 | 0.85 | SHMT1 (0.39) | SHMT1SHMT2MAPTTLR7 | |
| SCHEMBL1655299 | 0.82 | ATM (0.46) | KDM4ESMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL7425245 | 0.81 | HSD17B10 (0.39) | SHMT1SHMT2KDM4ESMN1; SMN2NPC1 | |
| SCHEMBL7426729 | 0.80 | TP53 (0.39) | SHMT1SHMT2SMN1; SMN2RAB9AMAPT | |
| SCHEMBL7382337 | 0.78 | MAPT (0.41) | SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL7424356 | 0.78 | HDAC1 (0.36) | SHMT1SHMT2SMN1; SMN2RAB9AMAPT | |
| SCHEMBL7421354 | 0.76 | NOTUM (0.46) | SMN1; SMN2NPC1RAB9ACYP2C9MAPT | |
| SCHEMBL7420766 | 0.76 | ALDH1A1 (0.47) | SHMT1SHMT2KDM4ESMN1; SMN2MAPT | |
| SCHEMBL5870566 | 0.75 | SHMT1 (0.60) | SHMT1SHMT2KDM4ESMN1; SMN2NPC1 | |
| SCHEMBL21560079 | 0.75 | SHMT1 (0.79) | SHMT1SHMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |